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KMID : 0380620160480050405
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Korean Journal of Food Science and Technology
2016 Volume.48 No. 5 p.405 ~ p.412
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Monitoring of illegal compounds and prohibited natural ingredients in foods
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Yun Ji-Suk
Choi Jang-Duck
Kwon Ki-Sung
Jo Cheon-Ho
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Abstract
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Illegally adulterated compounds, such as impotency drugs and their synthetic analogues, which have been purported to enhance sexual potency or mood, have been constantly detected in foods including dietary supplements. The adulterated foods with these illegal compounds may threaten public health because their safety and efficacy have not been verified. This study was aimed at investigating illegal compounds in foods and counterfeit products. 54 illegal compounds were assayed using a simultaneous analytical method involving liquid chromatography equipped with photo diode array (LC-PDA) and LC coupled with tandem mass spectrometry (LC-MS/MS). The method was validated in terms of selectivity, linearity, limit of detection (LOD), limit of quantification (LOQ), precision and accuracy. In 48 of 161 samples, we identified 7 different illegal compounds, including sildenafil, tadalafil, chlropretadalafil, demethylsildenafil, dimethylthiosildenafil, icariin and yohimbine. When purchasing products marketed for erectile dysfunction or aphrodisiacs, ulmost care should be taken owing to the possible presence of these illegal compounds.
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KEYWORD
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illegal compound, impotency drug, erectile dysfunction, phosphodiesterase type 5 inhibitor, adulteration
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